J Gen Virol
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J Gen Virol 24 (1974), 425-431; DOI 10.1099/0022-1317-24-3-425
© 1974 Society for General Microbiology
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DNA Synthesis in Resting African Green Monkey Kidney Cells Infected with Defective SV40

K. Kato, Sumie Watanabe, K. Yoshiike and S. Uchida

Department of Enteroviruses, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

SV40 (small-plaque type) generates heterogeneous defective virus particles during serial undiluted passages. DNA synthesis in resting African green monkey kidney cells infected with such defective particles was studied by autoradiography and band-sedimentation. The defective particles were found to have capacities to induce synthesis of cell DNA and to direct synthesis of virus DNA. The progeny virus DNA was more heterogeneous than the standard DNA.

Received 29 January 1974; accepted 26 April 1974.




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