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J Gen Virol 25 (1974), 143-145; DOI 10.1099/0022-1317-25-1-143
© 1974 Society for General Microbiology

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Interferon-Sepharose: priming of L Cells for Induction of Interferon by MM Virus

E. Knight, Jun.

Central Research Department E. I. du Pont de Nemours and Company, Wilmington, Delaware 19898, U.S.A.

Mouse L cells can be primed for enhanced interferon production by interferon covalently attached to beads of Sepharose. The induction of interferon synthesis by MM virus in primed cells can occur after removal of the interferon suggesting that interferon does not have to be in contact with the cell at the time of virus attachment. It is concluded that, like induction of the antiviral state, L cells can be primed at the cell surface for induction of interferon.

Received 11 March 1974; accepted 10 June 1974.





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Copyright © 1974 by the Society for General Microbiology.