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Focal Necrotic Hepatitis in Mice as a Biological Marker for Differentiation of Herpesvirus hominis Type 1 and Type 2

Institute of Medical Microbiology University of Aarhus, 8000 Aarhus C Denmark

Twenty-four strains of Herpesvirus hominis (HVH) were tested for their ability to produce large focal necrotic lesions in the liver of mice inoculated intraperitoneally with herpes virus. A close relationship was found between this property and infection with the type 2 strains and it is hoped that this observation may be used as a simple and reliable biological marker for the differentiation of HVH type 1 and type 2. Besides, it may draw the attention to a specific pathogenic distinction between these two types.

Received 25 May 1974; accepted 3 July 1974.