HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Radwan, A. I. Articles by Crawford, T. B. Search for Related Content PubMed PubMed Citation Articles by Radwan, A. I. Articles by Crawford, T. B. Agricola Articles by Radwan, A. I. Articles by Crawford, T. B.

The Mechanisms of Neutralization of Sensitized Equine Arteritis Virus by Complement Components

Department of Veterinary Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, U.S.A.

The mechanisms involved in the interaction of complement components with sensitized equine arteritis virus (EAV) were investigated. Virus neutralization and virolysis depended on both the concentration of the complement components and the concentration of the sensitizing antibody. High concentrations of C4, 2 and 3, with an optimal concentration of C1, were sufficient for neutralizing virus infectivity in the presence of excess antibody. The addition of the remaining five components (C5 to C9) of the complement system induced lysis of the previously neutralized virus particle. Lysis was initiated by C8 and was augmented by C9. Components C5 to C9 did not enhance neutralization produced by excess antibody and limiting concentrations of complement components. In contrast, addition of components C5 to C9 enhanced neutralization by means of lysis of the virus particle under conditions of low antibody concentration.

Received 4 December 1973; accepted 24 July 1974.

This article has been cited by other articles:

				E. Weiland, S. Bolz, F. Weiland, W. Herbst, M. J. B. Raamsman, P. J. M. Rottier, and A. A. F. De Vries Monoclonal Antibodies Directed against Conserved Epitopes on the Nucleocapsid Protein and the Major Envelope Glycoprotein of Equine Arteritis Virus J. Clin. Microbiol., June 1, 2000; 38(6): 2065 - 2075. [Abstract] [Full Text]