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The Effect of Isatin Thiosemicarbazone (IBT)-related Compounds on IBT-resistant and on IBT-dependent Mutants of Vaccinia Virus

The Chanock Centre for Virology, The Hebrew University — Hadassah Medical School, Jerusalem, Israel

IBT-related compounds were examined for their ability to inhibit wild-type and IBT-resistant mutants of vaccinia virus and for their capability to support the growth of an IBT-dependent mutant. Among thirteen compounds tested, six did not affect any one of the three virus strains and five behaved similarly to IBT, but two inhibited the growth of all three viruses and therefore differed from IBT. It was found that the last two compounds also differed from IBT in that they interfered with synthesis of the virus DNA. This difference is surprising in view of a substantial similarity in chemical structure.

Received 3 April 1974; accepted 24 July 1974.