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The Cytopathic Effect of Herpes Simplex Virus on HEp-2 Cells as shown by Scanning Electron Microscopy

Department of Clinical Pathology Clinical Laboratories San Francisco General Hospital, Potrero and 22nd Streets San Francisco, California 94110, U.S.A.

L. Drew and R. Hoo

Department of Pathology, Mount Zion Medical Center, San Francisco, California, U.S.A.

T. E. Everhart and Thea Scott

Department of Electrical Engineering University of California, Berkeley, California, U.S.A.

The c.p.e. of herpes simplex virus was studied by scanning electron microscopy. The infected cells showed changes in size, shape, numbers of microvilli, numbers and integrity of intercellular bridges, and surface of the monolayer. When substantiated, these alterations may prove to represent the early phases of cellular reaction to virus invasion.

^* To whom reprint requests should be addressed.

Received 10 May 1974; accepted 2 August 1974.