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Adenovirus Antigens: a Model System in Mice for Subunit Vaccination

Divisions of Virology and Immunology and Experimental Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K.

Mice can be immunized with the isolated capsid components of adenovirus (fibre and hexon) and the antibody response is largely thymus dependent. Immunized mice are protected against challenge with a lethal dose of adenovirus and this protection is type-specific for fibre, and mostly type-specific for hexon. The protection is antibody-mediated and there is an absolute requirement for a detectable level of circulating antibody to be present at the time of challenge. Although cell-mediated immunity is insufficient to protect against this particular disease syndrome, the possibility of its importance in protecting against natural adenovirus infection remains.

Received 3 June 1974; accepted 14 July 1974.

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