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Radioimmunoassay of the Group-specific Antigen in Detection of Avian Leukosis Virus Infection

T. Estola

S. Ristimäki

E. Ruoslahti

^* Department of Virology SF-00290 Helsinki 29, and
Department of Serology and Bacteriology, SF-00290 Helsinki 29,
University of Helsinki, SF-00290 Helsinki 29, Finland State Veterinary Medical Institute, SF-00550 Helsinki 55, Finland

The major group-specific antigen (gs-a) of avian leukoviruses was detected by radioimmunoassay in extracellular medium of all embryonic cultures prepared from infected chickens. Embryos of birds not carrying an avian leukosis virus infection and of chickens from a leukosis-free flock could thus clearly be distinguished from infected ones. Release of group-specific antigen into the extracellular medium was independent of subgroup or strain of avian leukosis or Rous sarcoma virus. The radioimmunoassay of the group-specific antigen seems to be well suited to complement the COFAL (complement fixation avian leukosis) and RIF (resistance inducing factor) tests in the detection of leukosis virus in infected material.

Received 13 June 1974; accepted 15 August 1974.