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J Gen Virol 26 (1975), 135-139; DOI 10.1099/0022-1317-26-1-135
© 1975 Society for General Microbiology
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Oxime Derivatives of Erythromycin: Inhibitors of Rous Sarcoma Virus Reverse Transcriptase Activity and Focus Formation

P. P. Hung

Department of Virology Abbott Laboratories, North Chicago, Illinois 60064, U.S.A.

9-O-methyloxime erythromycin A and its analogue inhibited reverse transcriptase and blocked focus formation of Rous sarcoma virus. These chemicals inhibited neither DNA-dependent DNA polymerase nor DNA-dependent RNA polymerase from bacterial sources. However, they inhibited reverse transcriptase with an apparently different mechanism than that by rifamycin ABDP.

Received 30 July 1974; accepted 19 September 1974.




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Copyright © 1975 by the Society for General Microbiology.