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J Gen Virol 26 (1975), 197-200; DOI 10.1099/0022-1317-26-2-197
© 1975 Society for General Microbiology
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The Influence of Emetine on the Induction of Interferon by Poly-I:Poly-C in Swiss Mice

H. Schellekens, J. H. P. M. Huffmeyer and L. J. L. D. Van Griensven

Department of Experimental Pathology, Medical Faculty Erasmus University, P.O. Box 1738, Rotterdam, Holland

The effect of emetine on the in vivo production of interferon by Swiss mice stimulated with poly-I:poly-C, was studied. 100 µg of emetine per mouse yielded a 16-fold increase in interferon production. Maximal production of interferon was achieved 2 h after the simultaneous injection of emetine and poly-I:poly-C.

Received 10 July 1974; accepted 8 October 1974.




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