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Venezuelan Equine Encephalomyelitis Virus (VEEV): Strain Differentiation and Specification of Virulence Markers

C. J. Bradish

^* Instituto Venezolano de Investigaciones Cientificas, Centro de Microbiologia y Biologia Celular, Laboratorio de Virus Animales, Apartado 1827, Caracas, Venezuela
Microbiological Research Establishment, Porton, Salisbury, England

Fourteen strains of VEEV of diverse origin and antigenicity were classified into five virulence categories according to their efficiency of infection and nature of response in mice. Mice of ages up to 30 days represented distinct levels of responsiveness and were suitable for the differentiation of VEEV strains of highest to lowest virulence. Stepwise changes with age of the susceptibility or responsiveness of mice appeared to determine the type of response as predominantly lethal (D), dual or intermediate (DP) or protective (P).

Received 12 July 1974; accepted 31 October 1974.