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Polyamine Metabolism in Cells Infected with Herpes Simplex Virus

Department of Biochemistry University of Cambridge, Tennis Court Road, Cambridge, England

Infection of LS cells with HSV-1 resulted in an inhibition of spermidine and spermine synthesis from putrescine, possibly through inhibition of host cell protein synthesis. The rate of putrescine uptake increased soon after infection, and later, polyamines were lost from the cells. Inhibition of spermidine and spermine synthesis by methylglyoxal bis(amidinohydrazone) did not affect virus replication.

Received 16 October 1974; accepted 6 December 1974.