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Interferon Induction in Mice by BHK Cells Persistently Infected with HVJ

Germfree Life Research Institute Nagoya University School of Medicine, Showa-Ku Nagoya, Japan

K. Shimizu and A. Kunii

1st Department of Internal Medicine Nagoya University School of Medicine, Showa-Ku Nagoya, Japan

Intraperitoneal injection into mice of BHK-HVJ cells (BHK cells persistently infected with HVJ) induced considerable amounts of circulating interferon. Sonication of BHK-HVJ cells almost totally abolished their interferon inducing capacities. This result suggests that a certain native organized structure of virus infected cells might be essential for production of interferon in this system, as is suggested in the in vitro system.

Received 18 July 1974; accepted 16 December 1974.