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The Effect of Interferon on the Formation of Virus Polyribosomes in L Cells Infected with Vaccinia Virus

Georgetta Danielescu

National Institute for Medical Research, Mill Hill, London NW7 1AA, England

The effect of interferon treatment of mouse L cells on the fate of virus messenger RNA following infection with vaccinia virus has been studied. The polyribosomes of interferon-treated, infected cells are found to be disaggregated and it is proposed that this results from inhibition of the initiation of virus polypeptide synthesis. Evidence is presented that inhibition of polypeptide chain elongation also occurs. The block in initiation appears to be due to the failure of the small ribosome subunit to attach to the virus messenger ribonucleoprotein complex. The translation of the different vaccinia messenger species is inhibited to a comparable extent.

^* Present address: Department of Microbiology, Rutgers Medical School, New Brunswick, New Jersey, U.S.A.

Present address: The ‘Stefan S. Nicolau’ Institute of Virology, 285 Sos. Mihai Bravu, Bucharest, Romania.

Received 21 October 1974; accepted 8 January 1975.