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Replication of Reticuloendotheliosis Viruses in Cell Culture: Chronic Infection

McArdle Laboratory, University of Wisconsin, Madison, Wisconsin 53706, U.S.A.

After an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. Essentially all of the chronically infected cells produced virus. The virus production was not sensitive to cytosine arabinoside or mitomycin C as was virus production in an acute infection.

The chronically infected cells had a strong group-specific resistance to the c.p.e. of superinfecting reticuloendotheliosis viruses. However, they were sensitive to vesicular stomatitis virus and avian leukosis-sarcoma viruses.

After double infection, single cells produced reticuloendotheliosis virus and avian leukosis-sarcoma virus.

Received 15 October 1974; accepted 22 January 1975.

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