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A Genetic Recombination Map of Foot-and-Mouth Disease Virus

Department of Genetics, Animal Virus Research Institute, Pirbright, Surrey GU24 0NF, U.K.

Sixty ts mutants were isolated from the Pacheco strain of type O foot-and-mouth disease virus after treatment with either 5-fluorouracil or hydroxylamine. The conditions affecting recombination and assay of the ts⁺ recombinants were standardized. Using two ts mutants resistant to guanidine, three-factor crosses, supported by two-factor crosses, located 34 of the mutations in a linear arrangement. The recombination frequencies between certain pairs of mutations were additive. The guanidine character of the two resistant mutants mapped as a single site mutation and was located near the middle of the map.

^* Present address: Shell Research Ltd., Sittingbourne, Kent ME9 8AG, U.K.

Received 5 November 1974; accepted 31 January 1975.