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Efficacy of Exogenous Interferon Treatment Initiated After Onset of Multiplication of Vesicular Stomatitis Virus in the Brains of Mice

Institut de Recherches Scientifiques sur le Cancer, 7, rue Guy Mocquet, 94800 Villejuif, France

Initiation of treatment with potent interferon preparations (6.4 x 10⁶ units per dose) 4 days after intranasal inoculation of VSV (at a time when virus has already multiplied in the brains of most mice) resulted in a marked increase in mouse survival. In a series of 6 experiments only 11 to 18% of control mice survived whereas 52% of interferon treated mice survived. These results suggest the usefulness of exogenous interferon even when treatment is begun late in the course of an acute virus disease.

Received 26 November 1974; accepted 14 February 1975.

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