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Clonal Variation of the Mouse Cells in the Endogenous C-type Virus Induction by 5-iodo-2'-deoxyuridine

Institut du Radium Biologie, Faculté des Sciences, Bâtiment 110, 91405 Orsay, France

Using an MLg cell line originating from a single newborn ddY mouse, N-tropic C-type virus able to infect the cells of origin was induced by 5-iodo-2'-deoxyuridine (IUdR). All the clones isolated from the MLg cell line released the virus after IUdR-treatment. There was more than a 100-fold difference in the virus inducibility between the highly and lowly inducible clones. The [¹²⁵I]-IUdR incorporation was, however, the same for the both types of clones.

When the induced virus was titrated in the S + L - C182 cells, the XC plaque titre was about tenfold higher than murine sarcoma virus rescue focus titre.

Received 28 January 1975; accepted 20 March 1975.