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Derivation of Mouse Sarcoma Virus (Kirsten) by Acquisition of Genes from Heterologous Host

Departments of Pathology, Biochemistry and Microbiology, University of Southern California School of Medicine, Los Angeles, California 90033, U.S.A.

The technique of virus RNA-cellular DNA hybridization in solution with DNA excess was used to compare the nucleotide sequences of the 70S RNA genome of the Kirsten mouse sarcoma virus (Ki-MSV) with that of mouse erythroblastosis virus (MEV) which gave rise to Ki-MSV after in vivo propagation in rat. It is suggested that a loss of about 30% of the genomic sequences of MEV with a concomitant gain of roughly equal amounts of rat-specific sequences in a genetically stable recombinant state led to the formation of Ki-MSV.

Received 21 January 1975; accepted 27 March 1975.

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