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The Effects of Concanavalin A on the Early Events of Infection by Rhinovirus Type 2 and Poliovirus Type 2

Central Research and Development Department, E. I. du Pont de Nemours and Company, Wilmington, Delaware 19898, U.S.A.

The effect of concanavalin A (Con A) on the course of early infection of HeLa cells with purified radioactive human rhinovirus type 2 (HRV-2) or poliovirus type 2 (P-2) has been examined. Several early steps in infection were inhibited before the uncoating of parental virus. Con A, at 100 µg/ml, reduces attachment of virus when added to cells before infection. Con A also detectably slows the normal progression of adsorbed virus to tightly bound forms characterized, in the case of HRV-2, by resistance to elution by EDTA, or in the case of P-2, by isolation of a characteristic virus-membrane complex. When Con A is added together with either virus, it also inhibits cell-mediated eclipse of infectivity and the formation of non-infective subviral particles.

Received 5 February 1975; accepted 24 April 1975.