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Inhibition of the Replication of Influenza A and B Viruses by a Nucleoside Analogue (Ribavirin)

Division of Virology, National Institute for Medical Research, Mill Hill London NW7 1AA

A synthetic nucleoside analogue 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin or RTCA) inhibits the replication in tissue culture of influenza B virus and also a wide range of influenza A viruses of human, animal and avian origin. The synthesis of influenza virus-induced antigens and also structural and non-structural polypeptides is inhibited by RTCA as detected by immunofluorescence and by pulse labelling experiments with [³⁵S]-methionine. The inhibitory effects of RTCA on influenza A virus replication in tissue culture is reversed by a molar excess of guanosine or xanthosine which suggests that the compound acts at an early stage of virus RNA synthesis prior to the utilisation of the latter nucleosides. A possible inhibitory effect of RTCA on cellular DNA replication is not excluded.

Received 4 February 1975; accepted 20 May 1975.

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