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The Polypeptide Structure of Transmissible Gastroenteritis Virus

Microbiology Department, Institute for Research on Animal Diseases, Agricultural Research Council, Compton, Newbury, Berkshire, U.K.

The polypeptides of purified preparations of the coronavirus responsible for transmissible gastroenteritis of pigs have been examined by polyacrylamide gel electrophoresis. Four major polypeptides, VP1 (mol. wt. 200000), VP2 (50000), VP3 (30000) and VP4 (28500) and two minor polypeptides, VP1a (105000) and VP1b (80500) have been reproducibly demonstrated in the virion, of which VP1, VP3 and VP4 contain carbohydrate. Treatment of the virion with the proteolytic enzyme bromelain removes the surface projections and VP1, thus identifying this glycopolypeptide as the major structural component of the projection.

Received 10 April 1975; accepted 10 June 1975.

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				S Resta, J. Luby, C. Rosenfeld, and J. Siegel Isolation and propagation of a human enteric coronavirus Science, September 6, 1985; 229(4717): 978 - 981. [Abstract] [PDF]