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The Cell to Cell Infection of Respiratory Syncytial Virus in HEp-2 Monolayer Cultures

T. Suto

Department of Bacteriology Tohoku University School of Medicine, Sendai, Japan

In general, the properties of respiratory syncytial virus are similar to those of myxoviruses (Chanock, Roizman & Myers, 1957; Hamparian, Hilleman & Ketler, 1963). One of the interesting properties of respiratory syncytial virus infection in vitro is syncytium formation (Jordan, 1962; Kisch, Johnson & Chanock, 1962). It has also been reported that the development of syncytia is influenced by the composition of the medium, the type of host cells (Jordan, 1962) and the incubation temperature (Suto et al. 1965), but it is not inhibited by the presence of virus antibody in the medium (Taylor-Robinson & Doggett, 1963). In the present studies, we report evidence of cell to cell infection with respiratory syncytial virus by successful transfer of virus antigen from infected cells to uninfected cells in the presence of antiviral serum.

The LONG strain of respiratory syncytial virus supplied by Dr R. M. Chanock (National Institutes of Health, Bethesda, Md, U.S.A.) was used throughout.

^* Present address: Roswell Park Memorial Institute, Buffalo, New York, U.S.A.

Present address: Department of Microbiology, Akita Prefectural Central Hospital, Akita, Japan.

Received 4 September 1967; accepted 10 February 1968.

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