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J Gen Virol 3 (1968), 35-42; DOI 10.1099/0022-1317-3-1-35
© 1968 Society for General Microbiology
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Interferon Production by Semliki Forest Virus Inactivated with Hydroxylamine

J. J. Skehel and D. C. Burke

Department of Biological Chemistry, Marischal College, University of Aberdeen, Scotland

The inactivation of Semliki Forest virus by hydroxylamine was a first-order reaction. The ability of the partially inactivated virus to induce the production of infective virus, virus haemagglutinin, virus-induced RNA synthesis, virus-induced RNA polymerase and interferon were all inactivated with first-order kinetics. It is concluded that functional nucleic acid is essential for interferon production in this system.

Received 14 October 1967; accepted 25 December 1967.




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Copyright © 1968 by the Society for General Microbiology.