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Studies on the Nature and Genetic Control of an Antigen in Normal Chick Embryos which Reacts in the COFAL Test

Houghton Poultry Research Station, Houghton, Huntingdon

Chick embryos from the inbred Reaseheath I line of chickens contained a complement-fixing antigen which reacted in the COFAL test, whereas embryos from the inbred Reaseheath C line lacked the antigen. In cross-bred embryos between the I and C lines the antigen segregated in accordance with the hypothesis that the presence of the antigen was controlled by a single autosomal dominant gene. The antigen appeared to be identical to the group-specific antigen of the avian leukosis-sarcoma group of viruses. No infectious virus was detected in I-line embryos, and the presence of the antigen was not correlated with response to the A and B subgroups of avian leukosis-sarcoma viruses. The possible relationship between the I-line antigen and viral group-specific antigen is discussed.

Received 18 March 1968; accepted 20 May 1968.

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