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Circulating Interferon in Mice Infected with the Lactate Dehydrogenase-elevating Virus

Sloan-Kettering Institute for Cancer Research, 145 Boston Post Road Rye, New York, 10580, U.S.A.

The lactate dehydrogenase-elevating virus (LDH-virus) (Riley et al. 1960; Riley, 1968) is unusual in a number of ways including its rapid rate of replication (its average replication cycle is approximately 30 min.), the production of high virus titres reaching peak concentrations of 10¹⁰ to 10¹¹ ID 50/ml. of blood plasma in 12 to 18 hr, and the rapid decline after 24 to 72 hr of 3 to 4 logarithms of virus infectivity to yield a stable lifelong viraemia of approximately 10⁴ to 10⁶ ID 50/ml. Both the acute and chronic viraemias are clinically benign with no evidence of any tissue damage, loss of weight, decrease in longevity, or cytopathic effects in the host.

An understanding of the nature of the unknown inhibitory or virus-limiting conditions responsible for the abrupt decrease in virus concentration and for its continued suppression is obviously pertinent. The possible role of interferon in this process is the subject of this report.

^* Present address: Department of Microbiology, Pacific Northwest Research Foundation, 1102 Columbia Street, Seattle, Washington 98104, U.S.A.

Received 6 February 1968; accepted 20 May 1968.

This article has been cited by other articles:

				V Riley, D. Spackman, G. Santisteban, G Dalldorf, I Hellstrom, K. Hellstrom, E. Lance, K. Rowson, B. Mahy, P Alexander, et al. The LDH virus: an interfering biological contaminant Science, April 14, 1978; 200(4338): 124 - 126. [PDF]