J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 3 (1968), 471-474; DOI 10.1099/0022-1317-3-3-471
© 1968 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barbanti-Brodano, G.
Right arrow Articles by la Placa, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barbanti-Brodano, G.
Right arrow Articles by la Placa, M.
Agricola
Right arrow Articles by Barbanti-Brodano, G.
Right arrow Articles by la Placa, M.

Thymidine Kinase Activity in Human Amnion Cell Cultures Infected with Shope Fibroma Virus*

G. Barbanti-Brodano, Marinella Portolani, A. Bernardini, F. Stirpe, Anna Mannini-Palenzona and M. la Placa

Istituto di Microbiologia and Istituto di Patologia generale Università di Bologna, Bologna, Italy

One of the ‘early’ effects of cellular infection by DNA-containing viruses is an increase of various enzymic activities concerned in DNA synthesis, which in most instances seems dependent upon the synthesis of virus-coded enzymes (Keir, 1968).

As far as poxviruses are concerned, relevant information relates almost exclusively to the vaccinia subgroup and very little is known about other poxviruses (Joklik, 1966).

The Shope fibroma virus is an oncogenic pox virus of the myxoma subgroup (Joklik, 1966) and has only recently been subjected to systematic study in tissue cultures. It has been shown to replicate in primary cell cultures of human amnion (Hodes et al. 1966; La Placa et al. 1967; Hodes & Chang, 1968) where it causes a peculiar cytopathic effect characterized by the appearance of pock-like lesions (La Placa et al. 1967). The time-course of nucleic acid synthesis (Ewton & Hodes, 1967) and the induction of DNA nucleotidyltransferase (Chang & Hodes, 1967) in cells infected with Shope fibroma virus have also been reported.

* Research supported in part by a grant from the Consiglio Nazionale delle Richerche (Contratto n. 115.2154.0/1760).

Received 13 June 1968; accepted 29 July 1968.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1968 by the Society for General Microbiology.