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J Gen Virol 30 (1976), 273
© 1976 Society for General Microbiology
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Proposed Nomenclature for Alphavirus Polypeptides

Investigators studying the molecular biology of Semliki Forest virus and Sindbis virus, two alphaviruses (previously group A arboviruses) met recently at the First International Symposium on Arboviruses in Helsinki. They proposed the following nomenclature for the virus-specific polypeptides formed in cells infected by these and similar viruses.

Proposed nomenclature for virus-specified polypeptides


Source Protein Notation to be used
Virion+cell: Core (capsid) C
Virion+cell: Envelope glycoproteins E1, E2, E3*
Cell: Polypeptides containing viral-structural amino-acid sequences p-molecular weight in thousands{dagger} (i.e. p-110)
Cell: Polypeptides containing non-structural amino-acid sequences ns-molecular weight in thousands (i.e. ns-78)

* From previous published reports the notation E2 and E3 are the cleavage products of the cellular precursor protein NVP 62–68 for Semliki Forest virus; for Sindbis virus, E2 is the product of the cellular Precursor noted as PE2.

{dagger} A relationship between the amino-acid sequences of a polypeptide and those of virus structural polypetides should be determined, before the p-molecular weight terminology is used.






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Copyright © 1976 by the Society for General Microbiology.