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Identification of Additional Antigenic Sites on Dane Particles and the Tubular Forms of Hepatitis B Surface Antigen

The Lindsley F. Kimball Research Institute of The New York Blood Center, New York, New York 10021, U.S.A.

Additional antigenic sites, distinct from those present on spherical 20 nm diam. particles of hepatitis B surface antigen (HB_sAg), are exposed on the surface of Dane particles and tubular forms of HB_sAg. The immunological relationship of these sites to e-antigen, an antigen detected earlier in HB_sAg-positive sera from patients with chronic hepatitis, cirrhosis or acute hepatitis but not in healthy HB_sAg-carriers, was established by immune electron microscopy and affinity chromatography. These findings suggest that e-antigen may be potentially useful in active immunization against hepatitis B.

^* Present address: Laboratoire d'Hygiene, Université de Lyon, Lyon, France.

Received 14 July 1975; accepted 15 October 1975.