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J Gen Virol 31 (1976), 145-148; DOI 10.1099/0022-1317-31-1-145
© 1976 Society for General Microbiology
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Mutants of Herpes Simplex Virus Types 1 and 2 that are Resistant to Phosphonoacetic Acid Induce Altered DNA Polymerase Activities in Infected Cells

J. Hay and J. H. Subak-Sharpe

M.R.C. Virology Unit, Institute of Virology, University of Glasgow, Glasgow G11 5JR

Three mutants of herpes simplex virus (HSV) have been isolated which form plaques in the presence of 100 µg/ml phosphonacetic acid (PPA). All three mutants (3 from HSV-1 strain 17 syn+, 14 from HSV-1 strain 17 syn, and 19 from HSV-2) induce viral DNA synthesis and viral DNA polymerase activity, and these are much less sensitive to PPA than the wild-type virus. The results support the hypothesis that PPA interacts directly with the viral DNA polymerase protein, at least part of which is virus coded.

Received 29 October 1975; accepted 12 December 1975.


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