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Permissiveness of Mouse, Monkey and Hybrid Cells to Encephalomyocarditis (EMC) Virus

Institut National de la Santé et de la Recherche Médicale, U.-43 Hôpital St.-Vincent-de-Paul, 74, avenue Denfert-Rochereau, 75014 Paris, France

Encephalomyocarditis (EMC) virus replicates to high titre in permissive mouse kidney (MKS) cells but poorly in monkey kidney (CV₁) cells. The permissiveness of monkey-mouse hybrid cells varies according to their chromosomal content.

In monkey cells, the synthesis of both single-stranded and double-stranded virus RNA is restricted; in semi-permissive hybrid clones, the double-stranded RNA is synthesized normally, whereas the synthesis of the single-stranded RNA is inhibited. Thus, it seems that more than one restrictive event is responsible for the low permissiveness of monkey cells to EMC virus.

Received 13 October 1975; accepted 17 December 1975.