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Herpes Simplex Virus Specified Deoxypyrimidine Kinase and the Uptake of Exogenous Nucleosides by Infected Cells

Medical Research Council, Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, Scotland

Herpes simplex virus can confer to thymidine kinaseless cells the ability to incorporate exogenously supplied thymidine into acid precipitable material. However no incorporation of exogenously supplied deoxycytidine into acid precipitable material can be detected after infection of deoxycytidine kinaseless cells by herpes simplex virus.

This failure to incorporate exogenous deoxycytidine is not due to the failure of the deoxycytidine phosphorylating activity of the virus induced deoxypyrimidine kinase but to a block in the metabolism of deoxycytidine monophosphate in herpes simplex virus infected cells. This block becomes evident with the appearance of the virus induced deoxypyrimidine kinase activity.

Received 26 September 1975; accepted 20 January 1976.