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J Gen Virol 31 (1976), 441-445; DOI 10.1099/0022-1317-31-3-441
© 1976 Society for General Microbiology
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The Membrane Location of Scrapie Infectivity

M. C. Clarke and G. C. Millson

ARC, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire, RG16 ONN, U.K.

Using 5'-nucleotidase and NADPH:cytochrome c reductase as respective enzyme markers for the plasma membrane and endoplasmic reticulum, a satisfactory separation of these two membrane fractions from a cell line (SMB) derived from a scrapie mouse brain has been achieved. The coincident distribution of scrapie infectivity and 5'-nucleotidase in various fractions isolated from these cells indicates that most of the scrapie infectivity present in this cell line is associated with the plasma membrane.

Received 11 December 1975; accepted 17 February 1976.




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Copyright © 1976 by the Society for General Microbiology.