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J Gen Virol 32 (1976), 133-137; DOI 10.1099/0022-1317-32-1-133
© 1976 Society for General Microbiology
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Evidence that Detergent-reactivated Interferons are not Renatured

P. T. Allen* and W. E. Stewart, II{dagger}

Rega Institute for Medical Research University of Leuven, 300 Leuven Belgium

The sedimentation rate of human leukocyte interferon (HLIF) reactivated from sodium dodecyl sulphate (SDS) solution was studied by glycerol gradient centrifugation and compared to that of native HLIF. Reactivated HLIF consistently sedimented faster than native HLIF, indicating that full recovery of antiviral activity does not require renaturation of the entire interferon molecule.

* Present address: Frederick Cancer Research Center, NCI, Fort Detrick, Frederick, Maryland, USA.

{dagger} Present address: Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France.

Received 13 August 1975; accepted 11 March 1976.




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Copyright © 1976 by the Society for General Microbiology.