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J Gen Virol 32 (1976), 143-147; DOI 10.1099/0022-1317-32-1-143
© 1976 Society for General Microbiology
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Suppression of Interferon Production by Vitamin A

J. E. Blalock and G. Gifford

Department of Immunology and Medical Microbiology University of Florida College of Medicine Gainesville, Florida, U.S.A.

Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.

Received 9 February 1976; accepted 22 March 1976.




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Copyright © 1976 by the Society for General Microbiology.