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J Gen Virol 32 (1976), 275-282; DOI 10.1099/0022-1317-32-2-275
© 1976 Society for General Microbiology
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Further Investigations on the Mode of Entry of Vaccinia Virus into Cells

Annabella Chang and D. H. Metz

National Institute for Medical Research, Mill Hill, London NW7 1AA, England

Earlier results indicating that vaccinia virus entered L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell have been confirmed and extended using immuno-ferritin conjugates to locate virus antigens on the host cell surface. After fusion, components of the virus envelope become rapidly dispersed in the plasma membrane. Fusion has also been observed as the predominant mode of entry of vaccinia virus into HeLa cells.

Received 5 February 1976; accepted 31 March 1976.


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