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J Gen Virol 33 (1976), 213-224; DOI 10.1099/0022-1317-33-2-213
© 1976 Society for General Microbiology

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RNA Synthesis in BHK 21 Cells Persistently Infected with Vesicular Stomatitis Virus and Rabies Virus

L. P. Villarreal and J. J. Holland

Department of Biology, University of California, San Diego, La Jolla, California 92093, U.S.A.

Virus-induced RNA synthesis was studied in BHK 21 cells persistently infected with vesicular stomatitis virus (VSV) and rabies virus by labelling RNA synthesized in the presence of actinomycin D. During persistent infection the species of messenger RNA synthesized were similar in size and relative proportions to those seen during acute infection, but there were some minor differences. Full-sized B virion RNA was generally not detected during persistent infection, and new species (probably DI virion RNA) appeared.

Received 16 March 1976; accepted 13 July 1976.


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J Holland, K Spindler, F Horodyski, E Grabau, S Nichol, and S VandePol
Rapid evolution of RNA genomes
Science, March 26, 1982; 215(4540): 1577 - 1585.
[Abstract] [PDF]




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Copyright © 1976 by the Society for General Microbiology.