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Antibody-induced Redistribution of Virus Antigens on the Surface of Influenza Virus-infected Cells

Heinrich-Pette-Institut für experimentelle Virologie und Immunologie an der Universität, Hamburg, Martinistrasse 52, 2000 Hamburg 20 Federal Republic of Germany

The behaviour of virus-specific antigen-antibody complexes at the plasma membrane of HeLa cells infected with influenza virus (A₀PR8) was studied by immunofluorescence- and immunoelectron-microscopy. As early as 7 h after infection the virus-induced plasma membrane antigens are evenly distributed over the surface of the infected cells. The addition of antiviral antibodies interferes with this distribution. The appearance of a subsequent patchlike and ‘capping’ distribution, followed by the disappearance of virus antigen-antibody complexes from the cell surface, is described. These findings demonstrate the potential mobility of virus-induced antigens in the plane of the cell surface.

Received 13 April 1976; accepted 16 July 1976.