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J Gen Virol 33 (1976), 345-349; DOI 10.1099/0022-1317-33-2-345
© 1976 Society for General Microbiology
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Gel Filtration of Hepatitis B Surface Antigen: Increased size of the native particle

R. Y. Dodd and J. A. Kobita

American National Red Cross Blood Research Laboratory, 9312 Old Georgetown Road Bethesda, Maryland 20014, U.S.A.

The Stokes radius of unpurified hepatitis B antigen (HBsAg) was determined by chromatography on a carefully calibrated Sepharose 4B column. A value of 14.2 nm was found by this procedure, contrasting with a published value of 11 nm for purified, pepsin-treated HBsAg. Chromatography at pH 3 appeared to reduce the Stokes radius of HBsAg to 11 nm. Evidence is presented to show that serum proteins adsorbed to HBsAg can be removed with pepsin or acid.

Received 12 December 1975; accepted 22 June 1976.




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Copyright © 1976 by the Society for General Microbiology.