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The Production and Action of Interferon in Chinese Hamster Cells

Department of Biochemistry, University of Leicester, Leicester LE1 7RH, England

The interferon system has been investigated in primary cell cultures established from Chinese hamster embryos and new born pups. Interferon synthesis was induced with Sindbis virus, ultraviolet irradiated Newcastle disease virus (u.v.-NDV) and with polyriboinosinic acid-polyribocytidylic acid complex [poly (rI). poly (rC)]. Only u.v.-NDV induced significant production of interferon, maximum amounts being produced in ‘aged’ cells. Its apparent mol. wt. was 25000. CHO-K1 cells, an established line of Chinese hamster cells, did not synthesize interferon in response to viruses, but were sensitive to its action.

Received 12 April 1976; accepted 30 June 1976.