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The Effects of Herpes Simplex Virus Type 1 on Cellular DNA-dependent RNA Polymerase Activities

Department of Biochemistry, Tennis Court Road, Cambridge, England

An investigation of the activity of nuclear RNA polymerase following infection of LS cells with HSV-1 shows a decline in both major activities. This effect is not entirely due to inhibition of cellular protein synthesis, and the effect of -amanitin-sensitive RNA polymerase is mediated by a protein(s) synthesized in the infected cell. Changes in the properties of this RNA polymerase activity include a reduction in the relative UTP/GTP incorporation ratio and an increased sensitivity to inhibition by actinomycin D, indicating that RNA polymerase II is involved in virus transcription.

^* Present address: Institute of Virology, Church Street, Glasgow G11 5JR, Scotland.

Received 8 April 1976; accepted 14 July 1976.

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