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J Gen Virol 33 (1976), 535-538; DOI 10.1099/0022-1317-33-3-535
© 1976 Society for General Microbiology
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Thymus Dependence of Rabies Vaccine

G. S. Turner

Lister Institute of Preventive Medicine, Elstree, Herts., U.K.

Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.

Received 1 July 1976; accepted 28 July 1976.




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Copyright © 1976 by the Society for General Microbiology.