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J Gen Virol 34 (1977), 1-8; DOI 10.1099/0022-1317-34-1-1
© 1977 Society for General Microbiology
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Vesicular Stomatitis Virus: Mode of Transcription

A. K. Banerjee, G. Abraham and R. J. Colonno

Department of Cell Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, U.S.A.

Recent studies on the mechanism by which the virion-associated RNA polymerase of vesicular stomatitis virus transcribes RNA have revealed several new biological features of general interest. The mode of synthesis of the 5'-terminal cap structure of the mRNAs, the sequential transcription of the genes and the presence of a transcribed ‘leader’ RNA segment are properties which are either not shown by other viruses, or have not yet been described. These features are probably inter-related with the primary transcription process, which itself may be a useful model for future studies on mRNA biosynthesis in eukaryotic systems.

Received 20 August 1976;


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