HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van der Groen, G. Articles by Pattyn, S. R. Search for Related Content PubMed PubMed Citation Articles by van der Groen, G. Articles by Pattyn, S. R. Agricola Articles by van der Groen, G. Articles by Pattyn, S. R.

Interaction of Mouse Peritoneal Macrophages with Different Arboviruses in vitro

D. A. R. Vanden Berghe

S. R. Pattyn

^* Institute for Tropical Medicine, B-2000 Antwerp
University of Antwerp, B-2610 Wilrijk, Belgium

In vitro cultured mouse peritoneal macrophages are inefficient host cells for both alpha and flaviruses tested. Production of infectious virus ceased 6 to 24 h after infection, except for virulent and avirulent SF strains. This limited growth is unrelated to interferon production. No correlation was found between the LD₅₀ of different virus strains for mice and the virus yields of in vitro infected macrophages therefrom. When macrophages from SF immunized mice were inoculated in vitro with SF or EEE, a cytopathic effect occurred, while the multiplication of SF, but not of EEE, was decreased. Virus multiplication in proteose peptone induced macrophages was enhanced for SF strains only. These results are discussed in relation to the virulence of several arboviruses for mice.

Received 6 August 1976; accepted 21 September 1976.