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J Gen Virol 34 (1977), 413-419; DOI 10.1099/0022-1317-34-3-413
© 1977 Society for General Microbiology
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Induction of Marek's Disease Virus Antigens by IdUrd in a Chicken Lymphoblastoid Cell Line

Kathi Dunn and K. Nazerian*

U.S. Department of Agriculture, ARS, Regional Poultry Research Laboratory, 3606 East Mount Hope, East Lansing, Michigan 48823

Marek's disease virus (MDV) antigens, as detected by immunofluorescence, were induced in a lymphoblastoid cell line, MSB-1, in the presence of IdUrd. When treated with 20 µg/ml of IdUrd there was no increase in the number of cells producing virus particles. If IdUrd was removed, an increase in virus production followed. Activation of the MDV genome appeared to require incorporation of IdUrd into cellular DNA and occurred during the first 12 h of culture. Expression of the activated genome required de novo protein synthesis and occurred during the next 12 h. The MDV genome in high producer MSB-1 cells could be activated with low concentrations of IdUrd, whereas low producer MSB-1 cells could not be activated with IdUrd to any great extent.

* To whom reprint requests should be addressed.

Received 1 July 1976; accepted 22 September 1976.


This article has been cited by other articles:


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M. S. Parcells, R. L. Dienglewicz, A. S. Anderson, and R. W. Morgan
Recombinant Marek's Disease Virus (MDV)-Derived Lymphoblastoid Cell Lines: Regulation of a Marker Gene within the Context of the MDV Genome
J. Virol., February 1, 1999; 73(2): 1362 - 1373.
[Abstract] [Full Text]


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Copyright © 1977 by the Society for General Microbiology.