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Effects of Ouabain on the Anticellular and Antiviral Activities of Human and Mouse Interferon

Department of Microbiology, School of Medicine, Chiba University, Chiba 280, Japan

When transformed human embryonic cells, RSa and RSb, were treated for 48 h with both 10^-7 M-ouabain and 1000 units/ml of human leucocyte interferon, there was an additive suppression of cell growth. In contrast, the antiviral action of the human interferon was inhibited by this concentration of ouabain. Similar effects of combined treatment with interferon and ouabain were found with IF^r cells (which are relatively resistant to the anticellular effect of interferon), and with mouse cells of the K3b line.

Received 17 May 1976; accepted 19 October 1976.