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Antiviral Activity in the Rabbit Cornea of Adenine Arabinoside, Ara-A 5' Monophosphate, and Hypoxanthine Arabinoside; and Interactions with Adenosine Deaminase Inhibitor

Department of Clinical Ophthalmology Institute of Ophthalmology University of London Moorfields Eye Hospital, London EC1 2PD

The multiple microtrephination technique was used in the rabbit cornea to compare the activity against herpes simplex virus (HSV) of adenine arabinoside (ara-A), ara-A 5' monophosphate (ara-AMP) and hypoxanthine arabinoside (ara-Hx), and to determine the effect of addition of adenosine deaminase inhibitor (ADAI) to each. The greatest antiviral activity was shown by ara-AMP, and the least by ara-Hx. ADAI increased the activity of ara-A but had no effect on ara-AMP or ara-Hx.

Received 1 February 1977; accepted 24 February 1977.