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A Mouse Model for Post-Exposure Rabies Prophylaxis: The Comparative Efficacy of Two Vaccines and of Antiserum Administration

Laboratory Investigations Section, Viral Zoonoses Branch, Viral Diseases Division, Bureau of Epidemiology, Center for Disease Control, Public Health Service, Department of Health, Education, and Welfare, Lawrenceville Facility, P.O. Box 363, Lawrenceville, Georgia 30246, U.S.A.

Mice challenged with rabies virus were vaccinated 24 h later with one of two types of rabies vaccine. Vaccine prepared from a BHK cell substrate resulted in the production of serum interferon and neutralizing antibody, whereas vaccine prepared from a human diploid cell substrate gave rise to neutralizing antibody but no interferon. Only the first vaccine was effective in reducing mortality.

Various combinations of mouse hyperimmune antiserum, purified IgG, complement and RNase were administered to other groups of mice challenged with rabies, but these had no significant effect on their survival.

Received 25 May 1976; accepted 4 February 1977.