J Gen Virol
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J Gen Virol 36 (1977), 249-255; DOI 10.1099/0022-1317-36-2-249
© 1977 Society for General Microbiology
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Amantadine-resistance as a Genetic Marker for Influenza Viruses

G. Appleyard

Microbiological Research Establishment, Porton, Nr Salisbury, Wiltshire, U.K.

The infection of eggs, cell cultures or mice with a mixture of amantadine-resistant and amantadine-sensitive strains of influenza virus resulted in the transfer of amantadine-resistance or sensitivity between strains. The response of a recombinant virus to amantadine was not related to either of its surface antigens. Resistance to amantadine was transferred as an all-or-none character. It is concluded that amantadine-resistance is a useful genetic marker for influenza viruses.

Received 7 February 1977; accepted 2 March 1977.


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