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Observations on the Antigenic Relationships Between Epstein-Barr Virus and Herpesvirus Saimiri

Department of Pathology, University of Bristol, Medical School University Walk, Bristol BS8 1TD, U.K.

The antigenic relationships between Epstein-Barr (EB) virus and herpesvirus saimiri (HVS) have been investigated in comparative immunofluorescence, microimmunodiffusion and serum neutralization tests. No similarity was detected between the structural antigens of the two herpesviruses but the results of micro-immunodiffusion tests showed that they shared a non-structural, virus-determined antigen. The implications of this finding are discussed in relation to the importance of HVS and its monkey lymphoma as a model system of herpesvirus oncogenesis.

Received 3 November 1976; accepted 16 March 1977.